MAP2K4 and MAPK12

Number of citations of the paper that reports this interaction (PubMedID 11062067)
49

Data Source:
HPRD (in vitro)

		MAP2K4	MAPK12
Description		mitogen-activated protein kinase kinase 4	mitogen-activated protein kinase 12
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axon Dendrite Cytoplasm Perikaryon	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Response To Wounding Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation	NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis
Drugs			Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		39 interacting genes: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 TRIB1 UBC	28 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		6416	6300
HPRD ID		03213	03868
Ensembl ID		ENSG00000065559	ENSG00000188130
Uniprot IDs		P45985	P53778 Q6N076
PDB IDs		3ALN 3ALO 3VUT	1CM8 4QUM
Enriched GO Terms of Interacting Partners?
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