ABCG4 and ABCG1

Number of citations of the paper that reports this interaction (PubMedID 15240127)
23

Data Source:
HPRD (in vitro, in vivo)

		ABCG4	ABCG1
Description		ATP binding cassette subfamily G member 4	ATP binding cassette subfamily G member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Golgi Membrane Mitochondrion Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Protein Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding ATP Binding Phospholipid Binding Cholesterol Binding ATPase Activity Toxin Transmembrane Transporter Activity Sterol-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Phosphatidylcholine-translocating ATPase Activity Intermembrane Cholesterol Transfer Activity
	Biological Process	Cholesterol Efflux Transmembrane Transport Cellular Response To Leukemia Inhibitory Factor	Cholesterol Metabolic Process Response To Organic Substance Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Lipid Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Glycoprotein Transport Cholesterol Homeostasis Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Protein Secretion Transmembrane Transport Phospholipid Homeostasis Cellular Response To High Density Lipoprotein Particle Stimulus Toxin Transport Positive Regulation Of Amyloid-beta Formation
Pathways		ABC transporters in lipid homeostasis	ABC transporters in lipid homeostasis HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			ATP
Diseases
GWAS		Lymphocyte counts ( 27863252) Neutrophil percentage of white cells ( 27863252)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Eating disorder in bipolar disorder ( 26433762) Gout ( 22179738) Idiopathic osteonecrosis of the femoral head ( 28000841) Neuritic plaque ( 25188341)
Interacting Genes		3 interacting genes: ABCG1 NLRX1 ZDHHC17	1 interacting genes: ABCG4
Entrez ID		64137	9619
HPRD ID		12130	04355
Ensembl ID		ENSG00000172350	ENSG00000160179
Uniprot IDs		Q9H172	P45844
PDB IDs
Enriched GO Terms of Interacting Partners?
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