FIGNL1 and ITGB1BP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FIGNL1	ITGB1BP1
Description		fidgetin like 1	integrin subunit beta 1 binding protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Microtubule-severing ATPase Activity Hydrolase Activity ATPase Activity	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Protein Kinase Binding
	Biological Process	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Cytoplasmic Microtubule Organization Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Regulation Of Blood Vessel Diameter Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)
Interacting Genes		7 interacting genes: C1orf112 DMC1 IDH1 ITGB1BP1 KDM1A RAD51 SPIDR	12 interacting genes: APP CAMK2A EEF1A1 FAF1 FIGNL1 ITGB1 KRIT1 LRP1 LRP2 LRP8 SMURF1 SMURF2
Entrez ID		63979	9270
HPRD ID		10958	06194
Ensembl ID		ENSG00000132436	ENSG00000119185
Uniprot IDs		B3KNH6 Q6PIW4	B4DQY5 O14713
PDB IDs		3D8B	1K11 4DX8 4DX9 4JIF
Enriched GO Terms of Interacting Partners?
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