DMRTA1 and STAT5B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DMRTA1	STAT5B
Description		DMRT like family A1	signal transducer and activator of transcription 5B
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Ovarian Follicle Development Regulation Of Transcription By RNA Polymerase II Male Mating Behavior	Luteinization Natural Killer Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-4 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration
Pathways			Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Dasatinib
Diseases			Growth hormone insensitivity with immunodeficiency
GWAS		Adventurousness ( 30643258) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Atopic dermatitis ( 25865352) Blood sugar levels ( 29403010) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 26956414) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Hemoglobin A1c levels ( 29403010) Hypertension ( 30487518) Lymphocyte counts ( 29403010) Metabolite levels ( 23823483) Monocyte count ( 29403010) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Pulse pressure ( 27841878) Systolic blood pressure ( 30224653) Tuberculosis ( 24057671) Type 2 diabetes ( 26818947 30718926) White blood cell count ( 29403010)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 27569725 28067908 23128233) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: ORC5 STAT5B	49 interacting genes: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		63951	6777
HPRD ID		10913	05037
Ensembl ID		ENSG00000176399	ENSG00000173757
Uniprot IDs		Q5VZB9	P51692
PDB IDs			6MBW 6MBZ
Enriched GO Terms of Interacting Partners?
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