UBE2O and CPNE4

Number of citations of the paper that reports this interaction (PubMedID 12522145)
33

Data Source:
HPRD (two hybrid, in vitro)

		UBE2O	CPNE4
Description		ubiquitin conjugating enzyme E2 O	copine 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Endopeptidase Activity Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Protein K63-linked Ubiquitination	Cellular Response To Calcium Ion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mitochondrial DNA levels ( 25240745)	Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis ( 22959728) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Body mass index ( 31453325 28892062 25673413) Body mass index variance ( 31453325) Circulating leptin levels in high cardiovascular risk ( 31766143) Coronary artery aneurysm in Kawasaki disease ( 27171184) Intracranial aneurysm ( 29531279) Iron status biomarkers (total iron binding capacity) ( 28334935) Metabolic syndrome ( 31589552) Motion sickness ( 25628336) Neutrophil count ( 21507922)
Interacting Genes		16 interacting genes: APPL1 BAP1 CPNE1 CPNE2 CPNE4 HEXIM1 ITCH MAF MDM2 PRKN RNF10 RNF31 SHBG TRIM27 UBC UBE2D3	16 interacting genes: ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O
Entrez ID		63893	131034
HPRD ID		10928	05017
Ensembl ID		ENSG00000175931	ENSG00000196353
Uniprot IDs		Q9C0C9	B7Z370 Q4G168 Q96A23
PDB IDs
Enriched GO Terms of Interacting Partners?
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