SDC1 and MDK

Number of citations of the paper that reports this interaction (PubMedID 9089390)
23

Data Source:
HPRD (in vitro)

		SDC1	MDK
Description		syndecan 1	midkine
Image
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Protein-containing Complex Lysosomal Lumen Extracellular Exosome	Extracellular Region Cytoplasm Cell Projection Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding
	Biological Process	Retinoid Metabolic Process Ureteric Bud Development Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Cell Migration Cytokine-mediated Signaling Pathway Wound Healing Odontogenesis Response To Hydrogen Peroxide Myoblast Development Leukocyte Migration Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Tissue Regeneration Response To Drug Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Interleukin-12 Secretion Positive Regulation Of Neuron Migration
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Other interleukin signaling Retinoid metabolism and transport	NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 28892062) Seasonality ( 25562672)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		16 interacting genes: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTEN PTN SDCBP	20 interacting genes: ALK FBXO7 JAK1 JAK2 LRP1 LRP2 LRP6 LRP8 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4
Entrez ID		6382	4192
HPRD ID		01718	01200
Ensembl ID		ENSG00000115884	ENSG00000110492
Uniprot IDs		P18827	P21741
PDB IDs		4GVC 4GVD 6EJE	1MKC 1MKN
Enriched GO Terms of Interacting Partners?
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