SCNN1G and SERP1

Number of citations of the paper that reports this interaction (PubMedID 22526458)
6

Data Source:
BioGRID (protein complementation assay)

		SCNN1G	SERP1
Description		sodium channel epithelial 1 subunit gamma	stress associated endoplasmic reticulum protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Integral Component Of Membrane
	Molecular Function	Ion Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding
	Biological Process	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis	Skeletal System Development Glucose Metabolic Process Cellular Protein Modification Process Protein Glycosylation Plasma Membrane Organization Post-embryonic Development Multicellular Organism Aging Protein Transport Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion IRE1-mediated Unfolded Protein Response Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion
Pathways		Stimuli-sensing channels	XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Triamterene Amiloride
Diseases		Liddle syndrome Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Heel bone mineral density ( 30598549)
Interacting Genes		13 interacting genes: COMMD10 EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 SOX4 STX1A USP10 WWP2	8 interacting genes: APP CANX LMNA SCNN1A SCNN1G SEC61A1 SEC61B TMEM79
Entrez ID		6340	27230
HPRD ID		02862	18037
Ensembl ID		ENSG00000166828	ENSG00000120742
Uniprot IDs		A5X2V1 P51170	Q9Y6X1
PDB IDs		6BQN
Enriched GO Terms of Interacting Partners?
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