ATXN1 and RBPMS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		ATXN1	RBPMS
Description		ataxin 1	RNA binding protein, mRNA processing factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix Nuclear Inclusion Body	P-body Nucleoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Poly(A) Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated RNA Processing Nervous System Development Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Nuclear Export	RNA Processing Response To Oxidative Stress Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 30061737 29892015) Breast cancer ( 29059683) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Cortical amyloid beta load ( 29860282) Gambling ( 22780124) General cognitive ability ( 29844566) Generalized epilepsy ( 30531953) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Subcutaneous adipose tissue attenuation (Hounsfield unit scale) ( 27918534) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 28714469) Total body bone mineral density ( 30172743) Visceral adipose tissue attenuation (Hounslow unit scale) ( 27918534) White blood cell count ( 29403010 27863252)	Blood urea nitrogen levels ( 31152163) Breast size ( 27182965) Granulocyte count ( 27863252) Heart rate variability traits ( 22174390) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular volume ( 29403010 27863252 28017375) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Platelet count ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Total grey matter volume ( 31530798)
Interacting Genes		251 interacting genes: - ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 H2AP H3C1 HEY2 HEYL HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS1 NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCC1L RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TENT5A TENT5B TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WASHC2C WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX	210 interacting genes: ABCF3 ADAM15 AMMECR1 ANKMY1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0D1 ATP6V0E2 ATXN1 BANP BBS2 BCL6B BHLHE40 BOLL C11orf87 C1orf94 C22orf39 C9orf24 CAMK2B CCER1 CCNG1 CCNK CDC23 CDC42EP1 CDK6 CHCHD7 CNNM3 CRBN CREB5 CRX CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DMRT3 DMRTB1 DOK3 DOK6 DPYSL4 DTX2 DVL2 EAF2 EFEMP2 ENKD1 EWSR1 EXOSC1 EYA2 FAM124B FAM168A FASTK FBF1 FBXL18 FNDC11 FOXC2 FOXP3 FOXS1 FRG1 FXR2 GATA1 GATAD2B GCM2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 GTF2F2 HEY2 HEYL HNRNPLL HOXA1 HOXA9 HOXB9 HOXC8 HSFY1 IGF2 ILF3 INCA1 INIP IP6K2 KCTD9 KIF1A KIR2DL4 KPNA2 KRAS KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP8-1 LASP1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LINC01869 LMO4 LONRF1 LRRC41 LZTS2 MAGED1 MCM5 MCM7 MEIS2 MGAT5B MKRN3 MORN3 MRPL20-AS1 MVP MYOZ2 NAB2 NANOG NAPRT NEDD9 NEU4 NR1D2 NTAQ1 NYNRIN OTX1 PATZ1 PDLIM4 PER1 PGLS PHF1 PICALM PIH1D1 PIN1 PITX1 PLAC8 POGZ POLR3GL POM121 PPP1R16B PRKAA1 PRKAA2 PRKAB2 PRR20A PSMF1 QKI R3HDM2 RABL6 RAD54L2 RAMAC RBFOX1 RBFOX2 RBM46 RDH12 RHOBTB3 RHOXF2 RIPPLY1 ROR2 RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SFI1 SH3RF2 SIRPB1 SMAD3 SMUG1 SNHG29 SNRPB SNRPC SPATA46 SPATA8 SPG7 STRBP TBX6 TCF7L2 TENT2 TEX37 TFG TIE1 TINAGL1 TLE5 TMSB4X TNS2 TOLLIP TOR1AIP2 TRAF4 TRIP13 TSG101 TTLL10 TUSC2 UBXN8 VENTX VHL VHLL VPS37C WDR54 WDR90 YPEL3 ZBTB32 ZC3H10 ZNF385C ZNF488 ZNF581
Entrez ID		6310	11030
HPRD ID		03333	11870
Ensembl ID		ENSG00000124788	ENSG00000157110
Uniprot IDs		P54253 Q96FF1	B4E3T4 D3DSV0 Q93062
PDB IDs		1OA8 2M41 4APT 4AQP 4J2J 4J2L	1BNY 5CYJ 5DET
Enriched GO Terms of Interacting Partners?
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