RYR3 and RYR2

Number of citations of the paper that reports this interaction (PubMedID 12213830)
12

Data Source:
HPRD (in vivo)

		RYR3	RYR2
Description		ryanodine receptor 3	ryanodine receptor 2
Image
GO Annotations	Cellular Component	Cell Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm	Cell Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma
	Molecular Function	Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Binding Calmodulin Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity	Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity
	Biological Process	Calcium Ion Transport Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Negative Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP Regulation Of Cardiac Conduction	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Response To Redox State Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Calcium-transporting ATPase Activity Regulation Of Cardiac Conduction
Pathways		Stimuli-sensing channels Ion homeostasis	Stimuli-sensing channels Ion homeostasis
Drugs			Tetracaine
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Catecholaminergic polymorphic ventricular tachycardia
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Carotid atherosclerosis in HIV infection ( 20009918) Hepcidin/ferritin ratio ( 27846281) Hippocampal volume ( 31530798) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260)	Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 30576415 24386095) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		5 interacting genes: BCL2L1 FKBP1A FKBP1B HNF1A RYR2	16 interacting genes: AKAP6 ALB CACNA1C FKBP1B HOMER1 HSPB2 ITPR1 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI
Entrez ID		6263	6262
HPRD ID		01620	01619
Ensembl ID		ENSG00000198838	ENSG00000198626
Uniprot IDs		A0A0U1RRH1 Q15413	Q92736
PDB IDs		4ERV	4JKQ
Enriched GO Terms of Interacting Partners?
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