RXRB and TFIP11

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		RXRB	TFIP11
Description		retinoid X receptor beta	tuftelin interacting protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromosome, Telomeric Region Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding	Nucleic Acid Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing Biomineral Tissue Development Negative Regulation Of Protein Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Protein Binding Negative Regulation Of DNA Ligase Activity Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	mRNA Splicing - Major Pathway
Drugs		Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Phthalic Acid Doconexent N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		Wegener's granulomatosis ( 23740775)
Interacting Genes		45 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12	128 interacting genes: ABI2 AIMP2 ANKRD11 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO AXIN1 BCL6 BMF C1orf109 C2CD6 CARD9 CCDC116 CCDC121 CCDC146 CCDC151 CCDC196 CCDC42 CCDC68 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CENPU CEP57 CEP57L1 CFAP206 COQ8A COX5B DGCR6 DISC1 EAF2 EIF3A FAM13C FAM156A FAM161A FAM50B FANCG GCC1 GEM GNG4 GOLGA1 GOLGA2 GPS2 GRAP2 HAUS1 HMG20B HOOK1 IKBIP IL16 IMP3 KANSL1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5L LENG1 LIN37 LMO1 LMO4 LSM3 LSP1P3 MCM7 MDM2 METTL17 MTFR2 NDC80 NDE1 NDN NFU1 OIP5 PBX4 PCM1 PDE4DIP POLL POLR1C PPP1R16A PPP1R16B PPP1R18 PRPF31 PSTPIP1 RCOR3 RHNO1 RNF6 RRP7A RXRB S100P SAP30BP SCNM1 SFR1 SH2D4A SH3GLB1 SMARCB1 SMARCE1 SNRPB SNW1 SNX20 SSX2IP STRN SYCE1 TCAF1 TDP2 TFPT THAP7 THAP8 TNNT1 TP53 TRAF3IP3 TRAPPC4 TSHZ3 TSPYL4 TUFT1 TXLNA USP6 USP7 VPS37C ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZSCAN12
Entrez ID		6257	24144
HPRD ID		01578	11628
Ensembl ID		ENSG00000204231	ENSG00000100109
Uniprot IDs		A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9	A0A024R1I7 Q9UBB9
PDB IDs		1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ
Enriched GO Terms of Interacting Partners?
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