RREB1 and NEUROD1

Number of citations of the paper that reports this interaction (PubMedID 12482979)
20

Data Source:
HPRD (in vitro)

		RREB1	NEUROD1
Description		ras responsive element binding protein 1	neuronal differentiation 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Nuclear Body Nuclear Speck Extracellular Exosome	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Ras Protein Signal Transduction Multicellular Organism Development Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Lamellipodium Morphogenesis	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JAK-STAT Cascade Embryonic Organ Morphogenesis Neuron Development Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		Age-related macular degeneration ( 20385826) Birth weight ( 31043758) Chronic kidney disease ( 29124443) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163 31451708 29124443) Ewing sarcoma ( 30093639) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252) Hyperuricemia ( 29124443) Lymphocyte counts ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 27863252) Multiple sclerosis ( 21833088) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418) Red blood cell count ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum uric acid levels ( 30993211 29124443) Sum basophil neutrophil counts ( 27863252) Type 2 diabetes ( 24509480 30054458 30297969 29632382 30718926) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 20884846 31578528 23263486) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Visceral adipose tissue adjusted for BMI ( 22589738 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 27863252)	Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138)
Interacting Genes		2 interacting genes: H3-4 NEUROD1	14 interacting genes: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 NR0B2 PDX1 PITX1 RREB1 TCF3 TCF4
Entrez ID		6239	4760
HPRD ID		03733	03428
Ensembl ID		ENSG00000124782	ENSG00000162992
Uniprot IDs		A0A024QZU8 Q92766	Q13562
PDB IDs
Enriched GO Terms of Interacting Partners?
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