BCS1L and ARHGAP18

		BCS1L	ARHGAP18
Description		BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	Rho GTPase activating protein 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding ATP Binding	GTPase Activator Activity Cadherin Binding
	Biological Process	Mitochondrion Organization Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex IV Assembly Mitochondrial Respiratory Chain Complex III Assembly	Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility
Pathways		Mitochondrial protein import	Rho GTPase cycle
Drugs
Diseases		Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Male-pattern baldness ( 28196072)	Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		14 interacting genes: AOX1 ARHGAP18 CD28 CLK1 CTLA4 DDX24 DNAJA1 MRPS12 MTDH ORC2 RP9 RPE SLC29A1 WDFY1	3 interacting genes: BCS1L MPHOSPH6 MPP6
Entrez ID		617	93663
HPRD ID		04708	12474
Ensembl ID		ENSG00000074582	ENSG00000146376
Uniprot IDs		A0A024R445 A8JZZ8 Q9Y276	Q8N392
PDB IDs
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