ROCK1 and RHOC

Number of citations of the paper that reports this interaction (PubMedID 8816443)
247

Data Source:
HPRD (in vivo)

		ROCK1	RHOC
Description		Rho associated coiled-coil containing protein kinase 1	ras homolog family member C
Image
GO Annotations	Cellular Component	Golgi Membrane Ruffle Extracellular Region Cytoplasm Centriole Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Lamellipodium Bleb Secretory Granule Lumen Amyloid-beta Complex	Cytoplasm Cytosol Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Division Site Cleavage Furrow Stereocilium Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Aspartic-type Endopeptidase Inhibitor Activity Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cytokinesis Aortic Valve Morphogenesis Apical Constriction Protein Phosphorylation Apoptotic Process Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Rho Protein Signal Transduction Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Neuron Projection Development Bleb Assembly Negative Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Myosin-light-chain-phosphatase Activity Neutrophil Degranulation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Negative Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Regulation Of Microtubule Cytoskeleton Organization Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Regulation Of Blood Vessel Diameter Regulation Of Angiotensin-activated Signaling Pathway Neuron Projection Arborization Positive Regulation Of Amyloid-beta Clearance Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Mitotic Cytokinesis Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Cell Shape Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs Neutrophil degranulation	Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs		Hydroxyfasudil (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Fasudil (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE Ripasudil Netarsudil
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Lysophosphatidylcholine levels ( 31551469) Telomere length ( 30185882)	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372)
Interacting Genes		35 interacting genes: ADD1 ARHGAP24 CASP3 CASP7 CDC25A CDC34 CFAP206 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MLC1 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TRIM15 TSG101 UBE2T VIM	7 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 ROCK1 RTKN
Entrez ID		6093	389
HPRD ID		03414	01322
Ensembl ID		ENSG00000067900	ENSG00000155366
Uniprot IDs		Q13464	A0A024R0C8 P08134
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P 5HVU 5KKS 5KKT 5UZJ 5WNE 5WNF 5WNG 5WNH 6E9W	1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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