EDA2R and C1QB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		EDA2R	C1QB
Description		ectodysplasin A2 receptor	complement C1q B chain
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Multicellular Organism Development Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Inner Ear Development Synapse Pruning
Pathways		TNFs bind their physiological receptors	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Zinc
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Balding ( 26926045) Male-pattern baldness ( 27182965 22032556 28196072)
Interacting Genes		7 interacting genes: C1QB CASP8 CEBPE EDA FADD TRAF3 TRAF6	10 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA
Entrez ID		60401	713
HPRD ID		02230	00394
Ensembl ID		ENSG00000131080	ENSG00000173369
Uniprot IDs		B2RBZ9 B4DQY6 Q9HAV5	A0A024RAB9 P02746
PDB IDs			1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ
Enriched GO Terms of Interacting Partners?
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