AFAP1 and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 12134071)
16

Data Source:
HPRD (in vivo)

		AFAP1	ACTC1
Description		actin filament associated protein 1	actin alpha cardiac muscle 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Focal Adhesion Actin Cytoskeleton	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Actomyosin, Actin Portion Cell Body Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Actin Binding SH3 Domain Binding SH2 Domain Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Cadmium levels ( 26025379) Diverticular disease ( 30177863) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105 27623284 29452408 25861811) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Lung function (FEV1/FVC) ( 30061609 30804560) Medication use (antiglaucoma preparations and miotics) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 27618447) Response to antidepressants (symptom improvement) ( 29160301) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Axial length ( 24144296) Refractive error ( 20835239)
Interacting Genes		9 interacting genes: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC	39 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		60312	70
HPRD ID		09747	00015
Ensembl ID		ENSG00000196526	ENSG00000159251
Uniprot IDs		Q6ZRV0 Q8N556	B3KPP5 P68032
PDB IDs
Enriched GO Terms of Interacting Partners?
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