RING1 and FHL1

Number of citations of the paper that reports this interaction (PubMedID 14999091)
12

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vivo)

		RING1	FHL1
Description		ring finger protein 1	four and a half LIM domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	Molecular_function Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition	Regulation Of Membrane Depolarization Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases			X-linked myopathy with postural muscle atrophy (XMPMA) Reducing body myopathy (RBM) Scapuloperoneal myopathy (SPM) Emery-Dreifuss muscular dystrophy
GWAS		Wegener's granulomatosis ( 23740775)
Interacting Genes		24 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 PHC1 PIK3R3 RB1 RNF2 RYBP TP53 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K	21 interacting genes: AKAP12 CBX4 CDC25C CHEK2 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE
Entrez ID		6015	2273
HPRD ID		03624	02157
Ensembl ID		ENSG00000204227	ENSG00000022267
Uniprot IDs		A0A1U9X8F2 Q06587	B7Z9A1 Q13642 Q5JXI2
PDB IDs			1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?
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