RGS3 and CNKSR2

Number of citations of the paper that reports this interaction (PubMedID 16637659)
25

Data Source:
HPRD (in vitro)

		RGS3	CNKSR2
Description		regulator of G protein signaling 3	connector enhancer of kinase suppressor of Ras 2
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Cytoplasm Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Inactivation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Regulation Of Signal Transduction Intracellular Signal Transduction Postsynapse Organization
Pathways		G alpha (q) signalling events G alpha (i) signalling events	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Height ( 28552196)	Bipolar disorder ( 31043756) Educational attainment (years of education) ( 30038396) Schizophrenia ( 25056061) Type 2 diabetes ( 30718926)
Interacting Genes		23 interacting genes: ACD APP CNKSR2 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ	13 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK
Entrez ID		5998	22866
HPRD ID		03720	06473
Ensembl ID		ENSG00000138835	ENSG00000149970
Uniprot IDs		A0A024R831 A0A024R833 A0A024R841 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3	A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2
PDB IDs		2F5Y 2OJ4 3FBK	2EAN 3BS5
Enriched GO Terms of Interacting Partners?
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