TRIM27 and UBE2I

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TRIM27	UBE2I
Description		tripartite motif containing 27	ubiquitin conjugating enzyme E2 I
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Early Endosome Cytosol PML Body Retromer Complex Nuclear Membrane	Synaptonemal Complex Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol PML Body Transferase Complex Sumoylated E2 Ligase Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding ATP Binding Transcription Factor Binding SUMO Transferase Activity Enzyme Binding HLH Domain Binding Small Protein Activating Enzyme Binding SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Adaptive Immune Response Negative Regulation Of Protein Kinase Activity Spermatogenesis Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Actin Nucleation Protein K63-linked Ubiquitination Interferon-gamma Secretion Negative Regulation Of Calcium Ion Import Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Viral Release From Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle Chromosome Segregation Viral Process Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of SUMO Transferase Activity
Pathways		SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis	Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474 29273806) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Childhood and early adolescence aggressive behavior ( 26087016) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate in diabetes ( 31451708) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Lung cancer in ever smokers ( 28604730) Neurociticism ( 29500382) Platelet aggregation ( 20526338) Pre-treatment viral load in HIV-1 infection ( 31219150) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Social communication problems ( 24047820)	Idiopathic dilated cardiomyopathy ( 29495422) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		270 interacting genes: ABCA1 ABCF3 ABHD17A AEN AMMECR1 AMOTL2 ARHGEF3 ARHGEF5 ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 AXIN1 BABAM1 BAG1 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C1orf109 CCDC102B CCDC198 CCDC87 CCDC92 CCHCR1 CDC20B CDC23 CDK18 CDKL3 CHCHD3 CHD4 CHUK CKS1B CLK2 CPNE2 CSNK2B CSRP2 CWF19L2 DCX DDX6 DGCR6 DMRT3 DNMT1 DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4E EIF4E2 EPC1 FAM110A FAM126A FAM126B FAM193B FAM214A FAM214B FAM83A FANCM FARS2 FBF1 FBXL19 FBXW5 FHL3 FNDC11 FOXB1 FOXC2 FXYD6 GATAD2B GCC2-AS1 GEM GFAP GFI1B GFM2 GLYCTK GNPDA2 GPANK1 GRB2 GTF2F1 HAUS1 HDAC1 HGS HNRNPLL HR IKBKB IKBKE ILF2 ILK INPP5J IQCE IQCN IQUB JOSD1 KANSL1 KAT14 KAT5 KCTD15 KCTD9 KIF1A KIF9 KIFC3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMO1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MTMR6 MVP NCK2 NDE1 NEBL NEDD9 NEIL2 NEK6 NELFE NIF3L1 NME7 NOTCH2NLA NR1D2 NTAQ1 NUDT21 OAS1 OTUB2 PIAS1 PIAS2 PIAS3 PIAS4 PIMREG PLEKHN1 PML POLE2 POLR1C POLR3C PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF31 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L RAB29 RAMAC RB1 RBM23 RBM41 RBX1 RCOR3 REL RHPN1 RIBC1 RNF213 RNF25 RNF6 RXRB SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SMARCB1 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 STK26 TBC1D22B TBK1 TCEA2 TCHP TEAD4 TLE5 TMSB4X TMSB4XP6 TP53 TPM3 TPRKB TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UBL5 UCHL3 UCHL5 UHRF2 USE1 USP2 UTP23 VPS25 VPS28 WT1-AS XPA YJU2 ZBTB16 ZC2HC1C ZFC3H1 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF384 ZNF417 ZNF446 ZNF572 ZNF581 ZNF688 ZNF79	376 interacting genes: ADAR ADD3 AGTRAP ANAPC4 ANXA1 APEX1 APP AR ARHGDIA ARL13B ARNT ARNTL ATF2 ATF3 ATF7IP ATXN1 AURKA AURKB BCAM BCL11A BEND5 BHLHE40 BIRC3 BIRC7 BLM BLMH BMI1 C18orf25 CALU CAMSAP2 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CCDC6 CD2AP CDC37 CDCA8 CDH4 CDKN1B CEBPD CEBPE CENPX CFTR CHD3 CHD4 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 COG1 CORO2A CREB1 CREBBP CREM CSNK2B CTBP2 CTNNA1 DACH1 DAXX DDX21 DDX24 DDX39A DDX5 DES DHX9 DNM1 DNMT3A DNMT3B DPYSL2 DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 ELK1 EP300 ESR1 ETS1 ETV1 ETV6 EXO1 EXOSC9 FAF1 FANCM FAS FHIT FHL3 FLI1 FMR1 FOS FOXL2 FOXM1 GCM1 GLUL GMCL1 GMCL2 GMEB1 GMEB2 GOLGA2 GOLGB1 GRIP1 GTF2I H4-16 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIF1A HIPK1 HIPK2 HIPK3 HIRA HMGB1 HMGN2 HNF4A HNRNPC HNRNPD HNRNPK HNRNPLL HNRNPM HNRNPU HSF1 HSF2 HSF2BP IKBKG IKZF1 IKZF3 IKZF5 IPO13 IQGAP1 JUN KAT2A KAT6B KCNA5 KCNK1 KCTD1 KDM1A KHSRP KLF3 KLF5 KLHL12 KMT5A KRT19 LATS1 LMNA LMO2 LNX2 MAP2K1 MAP3K1 MAPK1IP1L MARCHF5 MAT2A MATR3 MDM2 MECOM MED7 MEF2C MGRN1 MITF MKRN3 MRTFA MTA1 MYB MYBBP1A MYH9 NACC1 NAT10 NCOR2 NFKBIA NIN NMI NOL6 NONO NOP2 NOP56 NOP58 NOX5 NR1D2 NR1H2 NR1H3 NR1I2 NR3C1 NR3C2 NR5A1 NR5A2 NSD3 NUDCD3 NVL PARK7 PARP1 PDLIM7 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIM1 PLAAT4 PLAGL1 PML PPARA PPARG PPARGC1A PPM1J PRKAA2 PRKDC PRPF40A PRPF8 PSMC3 PSME3 PTEN PUF60 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RBM14 RBM25 RC3H2 RCBTB2 RFPL3 RHOXF2 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF185 RNF4 RNF40 RORB RPL11 RPL7 RPL8 RPS3A RPS6KA6 RWDD3 RXRA SAE1 SALL1 SART1 SATB1 SCNN1A SEMA6A SETBP1 SETDB1 SETX SFPQ SH3KBP1 SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SLX4 SMAD4 SNAI2 SND1 SNIP1 SNRNP200 SOCS6 SOX10 SOX4 SOX6 SOX9 SP100 SP3 SPECC1L SPOP SREBF1 SREBF2 SRF SSRP1 STAT1 STMN2 SUMO1 SUMO1P1 SUMO2 SUMO3 SUPT7L SUZ12 SYMPK TAB2 TAF1 TAF10 TAF12 TAF5 TBL1X TBL1XR1 TBP TCERG1 TCF3 TCF4 TDG TDP2 TERF2 TFAP2A TFAP2B TFAP2C TFCP2 THRA THRB TNFRSF1A TOP1 TOP2A TOP2B TOPORS TP53 TP63 TP73 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM24 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRIP13 TRPS1 TSHZ2 TSNAX UBA2 UBXN1 UCHL1 UNC119 USP25 VHL WNK1 WT1 WWP2 XBP1 XIAP XRCC1 XRCC5 ZBED1 ZBTB1 ZBTB16 ZBTB26 ZBTB7A ZBTB8A ZCCHC7 ZEB2 ZMYM2 ZNF106 ZNF24 ZNF451 ZNF646 ZNRD1
Entrez ID		5987	7329
HPRD ID		15996	09045
Ensembl ID		ENSG00000204713	ENSG00000103275
Uniprot IDs		A0A1U9X8R9 P14373	A8K503 B0QYN7 P63279
PDB IDs			1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X 5F6Y 5FQ2
Enriched GO Terms of Interacting Partners?
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