RFC1 and SSBP3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		RFC1	SSBP3
Description		replication factor C subunit 1	single stranded DNA binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Nucleolus Cytoplasm Elg1 RFC-like Complex Extracellular Exosome	Nucleus Transcription Factor Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity	Single-stranded DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Telomerase Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated Error-free Translesion Synthesis DNA Clamp Unloading	Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Cell Proliferation Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Head Development Head Morphogenesis Protein-containing Complex Assembly Positive Regulation Of Anterior Head Development
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching
Drugs
Diseases
GWAS		Asthma ( 30929738) Asthma (adult onset) ( 30929738) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)	Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 25673413) Food allergy ( 25710614) Menarche (age at onset) ( 27182965) P wave duration ( 28794112) Platelet distribution width ( 27863252) Serum bilirubin levels in metabolic syndrome ( 30621171) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149)
Interacting Genes		19 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC YWHAQ ZSCAN1	17 interacting genes: ANKEF1 APP ARNT2 CLK1 EWSR1 HCLS1 IL36RN LDB1 LDB2 NXT2 PIN1 RFC1 SIVA1 SUPT5H TBC1D23 YES1 ZNF226
Entrez ID		5981	23648
HPRD ID		00024	09578
Ensembl ID		ENSG00000035928	ENSG00000157216
Uniprot IDs		P35251	Q9BWW4 Q9NW25
PDB IDs		2EBU 2K6G 2K7F
Enriched GO Terms of Interacting Partners?
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