BCL2L1 and RBM5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		BCL2L1	RBM5
Description		BCL2 like 1	RNA binding motif protein 5
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	DNA Binding RNA Binding MRNA Binding Protein Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Mitotic Cell Cycle Checkpoint Germ Cell Development Spermatogenesis Cell Proliferation Positive Regulation Of Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Response To Virus Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Regulation Of Cytokinesis Response To Cytokine Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome	mRNA Splicing - Major Pathway
Drugs		4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Gossypol
Diseases
GWAS		Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Platelet count ( 27863252) Plateletcrit ( 27863252) Prudent dietary pattern ( 28644415) Putamen volume ( 29147026) Subcortical brain region volumes ( 25607358)	Age at first birth ( 27798627) Blood protein levels ( 28240269) Body mass index ( 26426971) Dentures ( 31235808) Extremely high intelligence ( 29520040) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Morning person ( 30696823) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Regular attendance at a gym or sports club ( 29970889) Sleep duration (short sleep) ( 30846698)
Interacting Genes		95 interacting genes: ACTB AKT1 ANTXR1 APAF1 AURKA AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIPL CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CHEK1 CREB3 CRYAA CRYAB CYCS DOCK7 EDRF1 FBP1 FKBP8 GLOD4 GSK3A GSK3B HNRNPA1 HRK IKZF3 IRS1 IRS2 LARP1 MAPK14 MAPK8 MAPK9 MAPKAPK2 MCL1 METTL23 MOAP1 MTNR1B MTOR NLRP1 PARK7 PDIA4 PLD3 PLK1 PLK3 PMAIP1 PPHLN1 PPP1CA PRKN PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 RNF183 RTN1 RTN4 RYR3 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TP53 TP53BP2 TPT1 UBR1 UHRF2 VAC14 VDAC1 ZFYVE1 ZHX1 ZNF219	22 interacting genes: BCL2L1 CASK DCX DDX17 GAPDH ILF3 KIF19 KIF9 LIG4 LRIF1 LSM8 MED1 MEOX1 MEOX2 NDEL1 PARD3B PCM1 PKP2 RBM14 WBP11 WDR77 ZDHHC17
Entrez ID		598	10181
HPRD ID		02497	06052
Ensembl ID		ENSG00000171552	ENSG00000003756
Uniprot IDs		A0A0S2Z3C5 Q07817 Q5TE63	A0A024R2U6 P52756
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2ME8 2ME9 2MEJ 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4BPK 4C52 4C5D 4CIN 4EHR 4HNJ 4IEH 4PPI 4QVE 4QVF 4QVX 4TUH 4Z9V 5AGW 5AGX 5B1Z 5C3G 5FMJ 5FMK 5VAY 5VX3 6BF2 6DCN 6DCO 6F46 6IJQ 6O0K 6O0L 6O0M 6O0O 6O0P 6RNU	2LK0 2LK1 2LKZ 5MF9 5MFY
Enriched GO Terms of Interacting Partners?
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