RBBP8 and DNA2

Number of citations of the paper that reports this interaction (PubMedID 25909997)
9

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RBBP8	DNA2
Description		RB binding protein 8, endonuclease	DNA replication helicase/nuclease 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Gamma DNA Polymerase Complex Mitochondrial Nucleoid
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Y-form DNA Binding Double-strand/single-strand DNA Junction Binding RNA Polymerase II Repressing Transcription Factor Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Protein Binding Identical Protein Binding Flap-structured DNA Binding	DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Nuclease Activity Protein Binding ATP Binding ATPase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base 5'-flap Endonuclease Activity Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Blastocyst Hatching DNA Replication DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Estradiol Cell Division Meiotic Cell Cycle Negative Regulation Of G0 To G1 Transition Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Nucleic Acid-templated Transcription	DNA Replication Checkpoint Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication Base-excision Repair Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair G-quadruplex DNA Unwinding Positive Regulation Of DNA Replication Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Regulation Of Signal Transduction By P53 Class Mediator Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination	Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint
Drugs
Diseases		Seckel syndrome
GWAS		Eosinophil percentage of white cells ( 27863252) Height ( 25429064 18391951) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Scalp hair shape ( 26926045) Tuberculosis ( 20694014)
Interacting Genes		37 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 USP4	2 interacting genes: RBBP8 TRAF6
Entrez ID		5932	1763
HPRD ID		04990	19123
Ensembl ID		ENSG00000101773	ENSG00000138346
Uniprot IDs		A0A024RC34 Q99708	P51530
PDB IDs		2L4Z 4D2H	5EAY
Enriched GO Terms of Interacting Partners?
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