ARID4A and CCNE1

Number of citations of the paper that reports this interaction (PubMedID 21148318)
11

Data Source:
BioGRID (enzymatic study)

		ARID4A	CCNE1
Description		AT-rich interaction domain 4A	cyclin E1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Transcriptional Repressor Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	DNA Binding Transcription Regulatory Region DNA Binding	Transcription Coactivator Activity Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription By RNA Polymerase II Spermatogenesis Histone H4-K20 Trimethylation Histone H3-K9 Trimethylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Histone H3-K4 Trimethylation Establishment Of Sertoli Cell Barrier	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Synapsis Wnt Signaling Pathway Androgen Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Localization
Pathways		HDACs deacetylate histones	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS		Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption in current drinkers ( 28937693) Coronary artery disease ( 29212778) Venous thromboembolism ( 31420334) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Bladder cancer ( 24163127 20972438) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 28135244 27841878) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458)
Interacting Genes		15 interacting genes: BRMS1 CCNA2 CCNB1 CCND1 CCNE1 CDK1 CDK2 CDK4 EID1 H3C14 H4-16 HDAC1 HDAC2 HDAC3 SIN3A	68 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A LATS2 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		5926	898
HPRD ID		01575	00455
Ensembl ID		ENSG00000032219	ENSG00000105173
Uniprot IDs		A0A024R657 A0A024R680 A0A024R6A2 P29374 Q05CG0	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		2LCC 2MAM 2YRV 6BPH	1W98 5L2W
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?