RASGRF1 and SNRNP70

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RASGRF1	SNRNP70
Description		Ras protein specific guanine nucleotide releasing factor 1	small nuclear ribonucleoprotein U1 subunit 70
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding
	Biological Process	MAPK Cascade Signal Transduction Small GTPase Mediated Signal Transduction Long-term Memory Cell Proliferation Neuron Projection Development Response To Endoplasmic Reticulum Stress Regulation Of Rac Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Activation Of GTPase Activity Regulation Of NMDA Receptor Activity	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) Myopia ( 27182965) Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Systolic blood pressure ( 30224653)
Interacting Genes		18 interacting genes: CEBPA EHD4 GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 TNK2 USP8 YWHAB YWHAE	41 interacting genes: APP ARSF CDKL3 CEP63 CHERP CRP CTDP1 DDX17 GEMIN2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2
Entrez ID		5923	6625
HPRD ID		07362	01617
Ensembl ID		ENSG00000058335	ENSG00000104852
Uniprot IDs		A8K270 Q13972 Q8IUU5	A0A024QZD5 P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9
Enriched GO Terms of Interacting Partners?
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