RARA and NCOA3

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RARA	NCOA3
Description		retinoic acid receptor alpha	nuclear receptor coactivator 3
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Surface Actin Cytoskeleton Dendrite Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Transcription Corepressor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Signaling Receptor Activity Histone Deacetylase Binding Protein Kinase B Binding Retinoic Acid-responsive Element Binding MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organism Development Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Hormone-mediated Signaling Pathway Negative Regulation Of Translation Hippocampus Development Cell Differentiation Prostate Gland Development Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Lipid Response To Cytokine Multicellular Organism Growth Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Embryonic Organ Development Gland Development Positive Regulation Of Binding Ventricular Cardiac Muscle Cell Differentiation Sertoli Cell Fate Commitment Limb Development Face Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus	Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Regulation Of RNA Biosynthetic Process
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)
GWAS		Asthma ( 31619474)	Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		89 interacting genes: ACTN4 AKT1 ARID1A ARID5A ARNTL BAG1 BTG1 CCND3 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIB3 TRIM24 TRIP4 UBE3A UBQLN1 USP7 ZBTB16	81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		5914	8202
HPRD ID		06769	03570
Ensembl ID		ENSG00000131759	ENSG00000124151
Uniprot IDs		A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7	Q59EE8 Q9Y6Q9
PDB IDs		1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13	1KBH 3L3X 3L3Z 6ES7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?