RAP2B and PDE6D

Number of citations of the paper that reports this interaction (PubMedID 11786539)
35

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		RAP2B	PDE6D
Description		RAP2B, member of RAS oncogene family	phosphodiesterase 6D
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Neutrophil Degranulation Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus
Pathways		Neutrophil degranulation	ARL13B-mediated ciliary trafficking of INPP5E
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Metabolite levels ( 23823483) Serum sulfate level ( 27412988)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		9 interacting genes: CAMK2B PDE6D PRKAR2B RALGDS RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	24 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		5912	5147
HPRD ID		01548	04056
Ensembl ID		ENSG00000181467	ENSG00000156973
Uniprot IDs		P61225	B8ZZK5 O43924 Q6IB24
PDB IDs		1N4P 1N4Q 1N4R	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
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