IL21 and IL21R

Number of citations of the paper that reports this interaction (PubMedID 11418623)
117

Data Source:
HPRD (in vivo)

		IL21	IL21R
Description		interleukin 21	interleukin 21 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding	Interleukin-21 Receptor Activity Transmembrane Signaling Receptor Activity Cytokine Receptor Activity
	Biological Process	Positive Regulation Of Cytokine Production Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Interleukin-21-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Maturation Positive Regulation Of Inflammatory Response	Natural Killer Cell Activation Interleukin-21-mediated Signaling Pathway
Pathways		Interleukin-21 signaling	Interleukin-21 signaling
Drugs
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 17558408 24999842 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342 20453842) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)	Asthma (childhood onset) ( 31036433) Bone mineral density ( 19874204) Leprosy ( 27976721) Mosquito bite size ( 28199695) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688)
Interacting Genes		3 interacting genes: DGKA FBXO25 IL21R	2 interacting genes: IL21 JAK1
Entrez ID		59067	50615
HPRD ID		05650	05649
Ensembl ID		ENSG00000138684	ENSG00000103522
Uniprot IDs		A0A224B028 Q9HBE4	Q9HBE5
PDB IDs		2OQP 3TGX	3TGX 4NZD
Enriched GO Terms of Interacting Partners?
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