RAD17 and USP20

Number of citations of the paper that reports this interaction (PubMedID 24923443)
10

Data Source:
BioGRID (enzymatic study)

		RAD17	USP20
Description		RAD17 checkpoint clamp loader component	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding ATP Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Mitotic DNA Replication Checkpoint Regulation Of Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Ub-specific processing proteases
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ATM ATR F2RL1 HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20	28 interacting genes: ALAS1 BEND5 BEND7 CLSPN DIO2 FATE1 GTF2IRD1 HIF1A IHO1 LMNA MAGEA11 MAPK6 MDFI PJA1 PLA2G2A PRKACA PRKCI RAD17 SPRY2 STING1 TRIM23 UBC ULK1 USP15 USP21 USP28 VAPB VHL
Entrez ID		5884	10868
HPRD ID		09124	07505
Ensembl ID		ENSG00000152942	ENSG00000136878
Uniprot IDs		O75943	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?
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