RAB5C and DGKI

		RAB5C	DGKI
Description		RAB5C, member RAS oncogene family	diacylglycerol kinase iota
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Lipid Droplet Plasma Membrane Endomembrane System Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Guanyl-nucleotide Exchange Factor Complex Protein-containing Complex Neuronal Cell Body Dendritic Spine Axon Terminus Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Schaffer Collateral - CA1 Synapse Extrinsic Component Of Presynaptic Active Zone Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity GTPase Inhibitor Activity Protein Binding ATP Binding Ras GTPase Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Rab Protein Signal Transduction Neutrophil Degranulation Plasma Membrane To Endosome Transport	Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neurotransmitter Secretion Platelet Activation Negative Regulation Of GTPase Activity Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Positive Regulation Of Ras Protein Signal Transduction Lipid Phosphorylation Habituation Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of Long-term Synaptic Depression Regulation Of Synaptic Vesicle Exocytosis
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)	Adventurousness ( 30643258) AIDS progression ( 21502085) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26865924) Cognitive decline (age-related) ( 24468470) General risk tolerance (MTAG) ( 30643258) Lean body mass ( 28552196) Schizophrenia ( 28991256 25056061 29483656 30285260) Testosterone levels in polycystic ovary syndrome ( 26284813)
Interacting Genes		19 interacting genes: APP APPL2 CCR10 DGKI EEA1 GLP1R HOXB13 HRAS INCA1 KRT15 RABAC1 RAPGEFL1 RBSN RIN2 RIN3 SGSM3 SLC27A2 TBC1D15 TBC1D17	2 interacting genes: RAB5C VHL
Entrez ID		5878	9162
HPRD ID		04947	07238
Ensembl ID		ENSG00000108774	ENSG00000157680
Uniprot IDs		A0A024R1U4 P51148	E7EWQ4 E9PFX6 O75912 Q59GE2
PDB IDs		4KYI
Enriched GO Terms of Interacting Partners?
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