MAP4K2 and HNRNPA2B1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MAP4K2	HNRNPA2B1
Description		mitogen-activated protein kinase kinase kinase kinase 2	heterogeneous nuclear ribonucleoprotein A2/B1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cell Cytoplasm Basolateral Plasma Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Single-stranded Telomeric DNA Binding Pre-mRNA Intronic Binding G-rich Strand Telomeric DNA Binding N6-methyladenosine-containing RNA Binding
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Viral Process RNA Metabolic Process Primary MiRNA Processing Interleukin-12-mediated Signaling Pathway G-quadruplex DNA Unwinding Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Transport Regulation Of RNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity MiRNA Transport
Pathways			mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Copper Artenimol
Diseases
GWAS		Urate levels ( 21768215)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6	19 interacting genes: CDKN2A CSNK2A1 CSNK2B ERG ESR1 H3-4 HIPK3 HNRNPL HSPB1 LIG4 MAP4K2 MCPH1 NR4A1 SNRNP70 SREK1 TTF2 VHL YAE1 ZMYM2
Entrez ID		5871	3181
HPRD ID		04408	02526
Ensembl ID		ENSG00000168067	ENSG00000122566
Uniprot IDs		A0A024R567 Q12851	P22626
PDB IDs			1X4B 5EN1 5HO4 5WWE 5WWF 5WWG
Enriched GO Terms of Interacting Partners?
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