RGL2 and RAP1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		RGL2	RAP1B
Description		ral guanine nucleotide dissociation stimulator like 2	RAP1B, member of RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Intracellular Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Ras Protein Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Ral Protein Signal Transduction	Cell Proliferation Response To Carbohydrate Microvillus Assembly Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Cellular Response To Drug Interleukin-12-mediated Signaling Pathway Neutrophil Degranulation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Gonadotropin-releasing Hormone Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways			Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	White blood cell count ( 20139978)
Interacting Genes		14 interacting genes: CCDC90B CRMP1 EEF1G HRAS KAT5 KAT7 KPNA2 KRAS NOTCH2NLA NRAS RAC1 RALA RAP1B UNC119	29 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		5863	5908
HPRD ID		03810	01546
Ensembl ID		ENSG00000237441	ENSG00000127314
Uniprot IDs		A0A024RCS9 O15211	A0A024RB87 B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6
Enriched GO Terms of Interacting Partners?
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