PYCR1 and NUDT21

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PYCR1	NUDT21
Description		pyrroline-5-carboxylate reductase 1	nudix hydrolase 21
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Cytoplasm Centrosome MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Nuclear Body Centriolar Satellite Paraspeckles
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Hydrolase Activity AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding
	Biological Process	Proline Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Processing Posttranscriptional Regulation Of Gene Expression Cell Differentiation MRNA 3'-end Processing Positive Regulation Of MRNA Cleavage Protein Tetramerization Protein Heterotetramerization Pre-mRNA Cleavage Required For Polyadenylation MRNA Alternative Polyadenylation Positive Regulation Of MRNA Polyadenylation Messenger Ribonucleoprotein Complex Assembly Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation
Pathways		Glutamate and glutamine metabolism	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		NADH L-Proline
Diseases		Geroderma osteodysplasticum
GWAS
Interacting Genes		4 interacting genes: BNIPL CDK2AP2 HNRNPD NUDT21	51 interacting genes: A2M ATXN1 CARM1 CEP126 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G ESR1 EXOSC6 F13A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIFAP3 MASP1 MYL6 NEDD4 NGEF NIF3L1 POLR2C PSMF1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 SEM1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP SNRNP70 SRPK1 TCERG1 TLE1 TRA2A TRIM27 WWOX
Entrez ID		5831	11051
HPRD ID		01528	05400
Ensembl ID		ENSG00000183010	ENSG00000167005
Uniprot IDs		A0A024R8U9 E2QRB3 J3QL32 P32322 Q8TBX0	A0A024R6W2 O43809
PDB IDs		2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX	2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T
Enriched GO Terms of Interacting Partners?
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