PEX5 and PAOX

Number of citations of the paper that reports this interaction (PubMedID 20178365)
16

Data Source:
BioGRID (unspecified method)

		PEX5	PAOX
Description		peroxisomal biogenesis factor 5	polyamine oxidase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex	Peroxisomal Matrix Cytosol
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding	Oxidoreductase Activity Polyamine Oxidase Activity N(1),N(12)-diacetylspermine:oxygen Oxidoreductase (3-acetamidopropanal-forming) Activity Spermine:oxygen Oxidoreductase (spermidine-forming) Activity Spermidine:oxygen Oxidoreductase (3-aminopropanal-forming) Activity N1-acetylspermine:oxygen Oxidoreductase (3-acetamidopropanal-forming) Activity N1-acetylspermidine:oxygen Oxidoreductase (3-acetamidopropanal-forming) Activity
	Biological Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Protein Import Into Peroxisome Membrane	Polyamine Biosynthetic Process Protein Targeting To Peroxisome Putrescine Biosynthetic Process Putrescine Catabolic Process Spermidine Catabolic Process Spermine Catabolic Process Oxidation-reduction Process Positive Regulation Of Spermidine Biosynthetic Process
Pathways		Pexophagy	PAOs oxidise polyamines to amines Interconversion of polyamines Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917)	Blood metabolite levels ( 24816252) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		71 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP2 USP9X ZNF772	1 interacting genes: PEX5
Entrez ID		5830	196743
HPRD ID		02684	10136
Ensembl ID		ENSG00000139197	ENSG00000148832
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	Q6QHF9
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO
Enriched GO Terms of Interacting Partners?
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