PTPRO and DPYSL4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PTPRO	DPYSL4
Description		protein tyrosine phosphatase receptor type O	dihydropyrimidinase like 4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity Cadherin Binding	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding
	Biological Process	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Protein Dephosphorylation Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Peptidyl-tyrosine Dephosphorylation Slit Diaphragm Assembly Regulation Of Synapse Organization Glomerular Visceral Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Pyrimidine Nucleobase Catabolic Process Nervous System Development Neuron Death Neuron Projection Guidance
Pathways		Signaling by NTRK3 (TRKC)	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Cognitive function ( 22126837) General cognitive ability ( 29844566) Glomerular filtration rate (creatinine) ( 26831199) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Intelligence (MTAG) ( 29326435) Obstetric antiphospholipid syndrome ( 28424481) Temporal pole volume ( 31530798)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 YWHAZ	8 interacting genes: DPYSL2 DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIP13
Entrez ID		5800	10570
HPRD ID		02784	07463
Ensembl ID		ENSG00000151490	ENSG00000151640
Uniprot IDs		A0A024RAS0 A0A024RAS9 Q16827	D3DRG7 O14531
PDB IDs		2G59 2GJT	5NKS
Enriched GO Terms of Interacting Partners?
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