PTPN12 and EIF4H

		PTPN12	EIF4H
Description		protein tyrosine phosphatase non-receptor type 12	eukaryotic translation initiation factor 4H
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection	Cytosol Polysome Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Translational Initiation Regulation Of Translational Initiation Viral Process Sexual Reproduction Developmental Growth
Pathways		SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462)
Interacting Genes		48 interacting genes: AATK ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR EIF4H ERBB3 ERBB4 FGFR2 FGFR4 FLT3 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2	7 interacting genes: C11orf68 CCL24 LAT2 LNX1 PTPN12 RFC2 STT3B
Entrez ID		5782	7458
HPRD ID		02513	11940
Ensembl ID		ENSG00000127947	ENSG00000106682
Uniprot IDs		B4E105 Q05209	Q15056
PDB IDs		5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?