LSM2 and ZNF408

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		LSM2	ZNF408
Description		LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	zinc finger protein 408
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex	Nucleus
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding Ral GTPase Binding	DNA Binding Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Femoral neck bone mineral density ( 29499414) Schizophrenia ( 29483656)
Interacting Genes		33 interacting genes: BANP CLNS1A CRMP1 DDX20 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PNMA1 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408	38 interacting genes: ATRN CALCOCO2 CCDC136 CEP70 CHAF1A CRELD1 DDX56 DVL3 EXOSC2 FBLN2 FHL2 GIPC1 GPATCH2L HOXA5 HOXB9 ID3 KHDRBS3 KRTAP4-12 LDOC1 LSM2 MDFI MIF PDE4DIP PDLIM4 PRAME PRNP PRPF31 RALYL SAP30BP THAP1 TOP3B UPF2 ZBTB8A ZBTB9 ZNF212 ZNF330 ZNF331 ZNF792
Entrez ID		57819	79797
HPRD ID		06282	18338
Ensembl ID		ENSG00000204392	ENSG00000175213
Uniprot IDs		Q9Y333	B4DXY4 Q9H9D4
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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