PITPNM2 and CPNE1

Number of citations of the paper that reports this interaction (PubMedID 12522145)
33

Data Source:
HPRD (in vitro)

		PITPNM2	CPNE1
Description		phosphatidylinositol transfer protein membrane associated 2	copine 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Endomembrane System Membrane Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transporter Activity Receptor Tyrosine Kinase Binding Phosphatidylcholine Binding Phosphatidylinositol Binding	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phospholipid Transport Phosphatidylinositol-mediated Signaling	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension
Pathways		Synthesis of PI	Glycerophospholipid biosynthesis Neutrophil degranulation
Drugs			Theophylline
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 25673412) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 27863252) Menopause (age at onset) ( 26414677) Multiple sclerosis ( 31604244 24076602) Platelet count ( 21507922) Schizophrenia ( 28991256 25056061 29483656 23974872) Tourette syndrome ( 30818990) Type 2 diabetes ( 30054458) Uterine fibroids ( 31649266)	Blood protein levels ( 30072576 29875488 28240269) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: CPNE1 CPNE4 PTK2B	18 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 STK3 UBE2M UBE2O WTAP
Entrez ID		57605	8904
HPRD ID		08335	05014
Ensembl ID		ENSG00000090975	ENSG00000214078
Uniprot IDs		Q9BZ72 Q9UF51	B0QZ18 Q99829
PDB IDs
Enriched GO Terms of Interacting Partners?
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