ADGRB2 and ARHGAP1

Number of citations of the paper that reports this interaction (PubMedID 14697242)
21

Data Source:
HPRD (two hybrid)

		ADGRB2	ARHGAP1
Description		adhesion G protein-coupled receptor B2	Rho GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Cytoplasm Cytosol Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	SH3/SH2 Adaptor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Rab GTPase Binding Cadherin Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peripheral Nervous System Development Negative Regulation Of Angiogenesis Calcineurin-NFAT Signaling Cascade Positive Regulation Of Synapse Assembly	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Transferrin Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling
Pathways			Rho GTPase cycle
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998 29785010) Smoking status (ever vs never smokers) ( 30643258)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)
Interacting Genes		8 interacting genes: ARHGAP1 GABPB1 HDHD2 LRP2BP SHANK1 SHANK2 SNTA1 STARD13	23 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B MTNR1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SMARCD3 SRC TAX1BP1 TUBA4A WAS
Entrez ID		576	392
HPRD ID		04063	04108
Ensembl ID		ENSG00000121753	ENSG00000175220
Uniprot IDs		O60241	Q07960
PDB IDs			1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V
Enriched GO Terms of Interacting Partners?
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