SRGAP1 and ROBO1

Number of citations of the paper that reports this interaction (PubMedID 11672528)
167

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SRGAP1	ROBO1
Description		SLIT-ROBO Rho GTPase activating protein 1	roundabout guidance receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Rac GTPase Binding	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Cell Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Rho GTPase cycle Inactivation of CDC42 and RAC1	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Cerebral microbleeds ( 31209788) Epithelial ovarian cancer ( 25134534)	Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Glomerular filtration rate in chronic kidney disease ( 26420894) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Schizophrenia ( 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920)
Interacting Genes		5 interacting genes: BMPR1B CDC42 FASLG RHOA ROBO1	8 interacting genes: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3
Entrez ID		57522	6091
HPRD ID		09406	03890
Ensembl ID		ENSG00000196935	ENSG00000169855
Uniprot IDs		Q7Z6B7	Q1RMC8 Q9Y6N7
PDB IDs			2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79
Enriched GO Terms of Interacting Partners?
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