MAVS and UBE4A

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (pull down)

		MAVS	UBE4A
Description		mitochondrial antiviral signaling protein	ubiquitination factor E4A
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Adaptor Activity CARD Domain Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Signal Transduction Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-beta Secretion Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		23 interacting genes: ABL1 BAG6 CALCOCO2 DDX3X DDX58 FASTKD5 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP3K7 OAS3 OTUD4 PLK1 RIPK2 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF6 UBE4A	11 interacting genes: CASP6 EPHA2 GZMB MAVS PTTG1 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		57506	9354
HPRD ID		13847	06793
Ensembl ID		ENSG00000088888	ENSG00000110344
Uniprot IDs		Q7Z434	Q14139
PDB IDs		2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK	1WGM
Enriched GO Terms of Interacting Partners?
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