PTGIS and PTGS2

Number of citations of the paper that reports this interaction (PubMedID 21035466)
10

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PTGIS	PTGS2
Description		prostaglandin I2 synthase	prostaglandin-endoperoxide synthase 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Caveola Protein-containing Complex Neuron Projection
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Transferase Activity Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Embryo Implantation Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Decidualization Negative Regulation Of Inflammatory Response Oxidation-reduction Process Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	Prostaglandin Biosynthetic Process Angiogenesis Inflammatory Response Response To Oxidative Stress Embryo Implantation Aging Learning Memory Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Fructose Response To Manganese Ion Response To Lithium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cyclooxygenase Pathway Lipoxygenase Pathway Bone Mineralization Ovulation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin D NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Cellular Response To Heat Response To Tumor Necrosis Factor Cellular Response To UV Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of Protein Import Into Nucleus Hair Cycle Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Vasoconstriction Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Decidualization Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Oxidation-reduction Process Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To Lead Ion Cellular Response To ATP Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Blood Vessel Diameter Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Angiotensin
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid	Dihomo-gamma-linolenic acid Icosapent Aminosalicylic Acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic Acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic Acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Dexibuprofen Firocoxib Alclofenac Acemetacin
Diseases			Esophageal cancer Cholangiocarcinoma Penile cancer
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)	Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		3 interacting genes: APP PTGS1 PTGS2	13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		5740	5743
HPRD ID		09046	02599
Ensembl ID		ENSG00000124212	ENSG00000073756
Uniprot IDs		Q16647	P35354
PDB IDs		2IAG 3B6H	1V0X 5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?
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