THAP11 and TPX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		THAP11	TPX2
Description		THAP domain containing 11	TPX2 microtubule nucleation factor
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Cytosol Intercellular Bridge	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding	Protein Binding Protein Kinase Binding Importin-alpha Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Regulation Of G2/M Transition Of Mitotic Cell Cycle Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs
Diseases
GWAS		Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)
Interacting Genes		18 interacting genes: C9orf16 CASP3 CTBP1 ECT2 HCFC1 HDAC1 HDAC3 HEMGN LRRC45 MCPH1 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52	7 interacting genes: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 THAP11
Entrez ID		57215	22974
HPRD ID		11629	05802
Ensembl ID		ENSG00000168286	ENSG00000088325
Uniprot IDs		Q96EK4	Q643R0 Q9ULW0
PDB IDs		2LAU 5AJS	1OL5 3E5A 3HA6 4C3P 5LXM 6BJC
Enriched GO Terms of Interacting Partners?
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