TRIM54 and MYO5B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM54	MYO5B
Description		tripartite motif containing 54	myosin VB
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GO Annotations	Cellular Component	Microtubule Microtubule Associated Complex Z Disc	Cytoplasm Actin Cytoskeleton Myosin Complex Cytoplasmic Vesicle Membrane Vesicle Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding Actin-dependent ATPase Activity Actin Filament Binding
	Biological Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organism Development Cell Differentiation	Renal Water Homeostasis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport Vesicle Transport Along Actin Filament
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 29084231) Large HDL particle concentration ( 29084231) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		132 interacting genes: ADCY4 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 C2CD6 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC87 CDK18 CDKN1A CENPX CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DEUP1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 HSPB1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 NTAQ1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM TBC1D22B TCEA2 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587	13 interacting genes: AMOTL2 BNIP2 COIL CXCR2 KIAA1549 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SMAD3 TCF4 TRIM54
Entrez ID		57159	4645
HPRD ID		05928	07582
Ensembl ID		ENSG00000138100	ENSG00000167306
Uniprot IDs		Q9BYV2	Q7Z7A5 Q9ULV0
PDB IDs		3Q1D	4J5M 4LNZ 4LWZ 4LX0
Enriched GO Terms of Interacting Partners?
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