AVEN and APAF1

Number of citations of the paper that reports this interaction (PubMedID 10949025)
51

Data Source:
HPRD (two hybrid, in vivo)

		AVEN	APAF1
Description		apoptosis and caspase activation inhibitor	apoptotic peptidase activating factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Endomembrane System Membrane	Extracellular Region Nucleus Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neutrophil Degranulation Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Formation of apoptosome Regulation of the apoptosome activity	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			ATP
Diseases
GWAS
Interacting Genes		4 interacting genes: APAF1 BCL2L1 PMPCA SMURF1	18 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1
Entrez ID		57099	317
HPRD ID		05588	03755
Ensembl ID		ENSG00000169857	ENSG00000120868
Uniprot IDs		Q9NQS1	O14727
PDB IDs			1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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