KNL1 and TTK

Number of citations of the paper that reports this interaction (PubMedID 22660415)
127

Data Source:
BioGRID (enzymatic study)

		KNL1	TTK
Description		kinetochore scaffold 1	TTK protein kinase
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body	Kinetochore Nucleus Cytoplasm Spindle Membrane
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinetochore Binding
	Biological Process	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division	Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Female Meiosis Chromosome Segregation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Meiotic Spindle Assembly Checkpoint Protein Localization To Kinetochore Protein Autophosphorylation Chromosome Separation Protein Localization To Meiotic Spindle Midzone
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379)	Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16
Entrez ID		57082	7272
HPRD ID		10634	04973
Ensembl ID		ENSG00000137812	ENSG00000112742
Uniprot IDs		Q8NG31	P33981
PDB IDs		3SI5 4A1G 4NF9 4NFA	2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O
Enriched GO Terms of Interacting Partners?
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