EXOSC5 and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid, in vitro)

		EXOSC5	EXOSC1
Description		exosome component 5	exosome component 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		45 interacting genes: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DMRTB1 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FHL3 GOLGA2 HAMP HBS1L IKZF3 KIAA1217 KMT2A KRT13 LIPG LSM3 LSM5 MPHOSPH6 MPP6 MTREX NMI NUP210 PA2G4 PAF1 PKM POLR2L PRODH2 REL SFPQ SH3GLB1 SH3GLB2 TEX11 TNFAIP1 TRIM54 ZNF558	27 interacting genes: A2M APP CDC37 DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FHL3 KCTD1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1
Entrez ID		56915	51013
HPRD ID		16222	16223
Ensembl ID		ENSG00000077348	ENSG00000171311
Uniprot IDs		Q9NQT4	B1AMU3 Q9Y3B2
PDB IDs		2NN6 6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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