WRNIP1 and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (affinity chromatography technology, pull down)

		WRNIP1	TOLLIP
Description		WRN helicase interacting protein 1	toll interacting protein
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Cytosol Nuclear Body Azurophil Granule Lumen Specific Granule Lumen Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATPase Activity Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity Identical Protein Binding Metal Ion Binding	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Regulation Of DNA Repair Regulation Of DNA-dependent DNA Replication Initiation DNA Duplex Unwinding Positive Regulation Of Catalytic Activity Innate Immune Response	Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Neutrophil Degranulation Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways			Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS			Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		12 interacting genes: ABL1 PCNA PIK3R3 PIN1 POLD1 POLD2 POLD4 RIPK1 TOLLIP TRIM14 UBC WRN	44 interacting genes: ACTN2 ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 GGA1 GGA2 GGA3 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 NTAQ1 ODAM PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPTIN1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WBP2 WRNIP1 XRN2 ZBTB16 ZHX1
Entrez ID		56897	54472
HPRD ID		10494	05887
Ensembl ID		ENSG00000124535	ENSG00000078902
Uniprot IDs		Q96S55	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		3VHS 3VHT	1WGL 2N31
Enriched GO Terms of Interacting Partners?
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