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PSMA6 and SIRPA
Number of citations of the paper that reports this interaction (PubMedID
19299420
)
12
Data Source:
BioGRID
(pull down)
PSMA6
SIRPA
Description
proteasome 20S subunit alpha 6
signal regulatory protein alpha
Image
GO Annotations
Cellular Component
Proteasome Complex
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Polysome
Nuclear Matrix
Proteasome Core Complex, Alpha-subunit Complex
Myofibril
Sarcomere
Extracellular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Membrane
Extracellular Exosome
Tertiary Granule Membrane
Ficolin-1-rich Granule Membrane
Molecular Function
RNA Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Purine Ribonucleoside Triphosphate Binding
NF-kappaB Binding
SH3 Domain Binding
Protein Phosphatase Binding
GTPase Regulator Activity
Protein Binding Involved In Heterotypic Cell-cell Adhesion
Cell-cell Adhesion Mediator Activity
Protein Antigen Binding
Protein Tyrosine Kinase Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Protein Catabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Proteolysis Involved In Cellular Protein Catabolic Process
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Protein Phosphorylation
Cell Adhesion
Regulation Of Gene Expression
Cell Migration
Positive Regulation Of Cell-cell Adhesion
Regulation Of Interferon-gamma Production
Regulation Of Interleukin-1 Beta Production
Regulation Of Interleukin-6 Production
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Interferon-beta Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
Monocyte Extravasation
Neutrophil Degranulation
Negative Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis
Regulation Of Catalytic Activity
Positive Regulation Of T Cell Activation
Leukocyte Migration
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Interleukin-12
Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production
Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of I-kappaB Phosphorylation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK - noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Cell surface interactions at the vascular wall
Signal regulatory protein family interactions
Signal regulatory protein family interactions
Neutrophil degranulation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Creatine kinase levels (
29403010
)
Psoriasis (
25903422
20953189
)
Aortic root size (
21223598
)
Basophil percentage of granulocytes (
27863252
)
Blood protein levels (
30072576
29875488
)
Liver enzyme levels (alanine transaminase) (
24124411
)
Mean platelet volume (
22139419
19820697
27863252
)
Platelet count (
29403010
)
Interacting Genes
27 interacting genes:
ALKBH4
BRCA1
C19orf57
CADM1
ECT2
HSPB1
KRTAP4-2
LIG4
LIMD2
NEDD8
PAXIP1
PLK1
PSMA2
PSMA3
PSMA4
PSMA7
PSMB5
PSMB6
PSMB8
PSMC6
RNF170
RTP5
SIRPA
TRIM39
UBC
USP4
ZBTB44
57 interacting genes:
ACTN1
AKT1
ARF4
ARHGEF6
CALR
CAPZB
CCDC57
CD47
CD81
CDK16
COL6A2
DDX10
EIF5B
ELOA
FBN2
FLNA
FTH1
FUBP1
GNL1
HSP90AB1
HSP90B1
HSPA4
HSPA5
HSPA8
HSPA9
IGF1R
IL1RAP
JAK2
KRT10
KRT15
KRT2
KRT31
KRT40
KTN1
MATK
MT-ND1
MX1
NEK1
NEXN
NOL3
NUCB1
PFN1
PHYH
PPM1B
PSMA6
PSMC5
PTPN11
PTPN6
PTPN7
RPS8
SAFB2
SMG7
SOS1
TBX3
TRIM2
TRIM27
VIM
Entrez ID
5687
140885
HPRD ID
04171
03912
Ensembl ID
ENSG00000100902
ENSG00000198053
Uniprot IDs
A0A140VK44
P60900
P78324
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6MSB
6MSD
6MSG
6MSH
6MSK
6R70
6REY
6RGQ
2JJS
2JJT
2UV3
2WNG
4CMM
6BIT
6NMR
6NMS
6NMT
6NMU
6NMV
Enriched GO Terms of Interacting Partners
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