PROX1 and IRF4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PROX1	IRF4
Description		prospero homeobox 1	interferon regulatory factor 4
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Transcription Regulatory Region DNA Binding DBD Domain Binding LBD Domain Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Brain Development Circadian Rhythm Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Optic Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Population Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Immune System Process Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis
Pathways			Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Birth weight ( 31043758) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Hematocrit ( 29403010 27863252) Hemoglobin ( 29403010) Hemoglobin concentration ( 27863252) HIV-1 progression ( 20064070) Homeostasis model assessment of beta-cell function ( 20081858) Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484) Obesity ( 23818313) Red blood cell count ( 29403010 27863252) Triglycerides ( 25961943) Type 2 diabetes ( 28566273 22885922 24509480 29358691 30297969) Type 2 diabetes (age of onset) ( 28060188)	Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 30664655 29662168 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Monobrow ( 27182965) Nevus count ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 25574825 23143594) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203) Vitiligo ( 27723757)
Interacting Genes		17 interacting genes: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	20 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 USP4 YTHDC2
Entrez ID		5629	3662
HPRD ID		03330	03543
Ensembl ID		ENSG00000117707	ENSG00000137265
Uniprot IDs		Q92786	Q15306
PDB IDs		2LMD	2DLL
Enriched GO Terms of Interacting Partners?
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