PARD3 and TIAM2

Number of citations of the paper that reports this interaction (PubMedID 15723051)
146

Data Source:
HPRD (in vitro, in vivo)

		PARD3	TIAM2
Description		par-3 family cell polarity regulator	TIAM Rac1 associated GEF 2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Apical Junction Complex Axonal Growth Cone	Cytosol Membrane Lamellipodium Filopodium Growth Cone Perikaryon Synapse Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Rac Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Lipid Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	NRAGE signals death through JNK Rho GTPase cycle PPARA activates gene expression G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		28 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ	9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1
Entrez ID		56288	26230
HPRD ID		05994	05273
Ensembl ID		ENSG00000148498	ENSG00000146426
Uniprot IDs		Q8TEW0	B3KW11 Q8IVF5
PDB IDs		2KOM
Enriched GO Terms of Interacting Partners?
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