PRL and PPIB

Number of citations of the paper that reports this interaction (PubMedID 10935542)
24

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PRL	PPIB
Description		prolactin	peptidylprolyl isomerase B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen	Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Prolactin Receptor Binding Hormone Activity Protein Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Unfolded Protein Binding RNA Polymerase Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Positive Regulation Of Cell Proliferation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Regulation Of Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of JAK-STAT Cascade JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Lactation	Protein Peptidyl-prolyl Isomerization Positive Regulation Of Multicellular Organism Growth Protein Refolding Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification
Pathways		Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling	Collagen biosynthesis and modifying enzymes
Drugs			L-Proline 1,4-Dithiothreitol
Diseases			Osteogenesis imperfecta
GWAS		Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		4 interacting genes: PPIB PRLR SCARB1 UBQLN4	19 interacting genes: APOB ATP12A BANP CAMLG DNM2 ESR1 GLP1R H3-4 IRF3 MDM2 PEX19 PRL SGTA SGTB STAT5A TP53 UBQLN1 UBQLN4 VKORC1
Entrez ID		5617	5479
HPRD ID		07180	00458
Ensembl ID		ENSG00000172179	ENSG00000166794
Uniprot IDs		P01236 Q5I0G2 Q5THQ0	P23284
PDB IDs		1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ	1CYN 3ICH 3ICI
Enriched GO Terms of Interacting Partners?
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